{"id":23531,"date":"2025-04-13T17:39:56","date_gmt":"2025-04-13T17:39:56","guid":{"rendered":"https:\/\/researchchemicalstore.net\/?post_type=product&p=23531"},"modified":"2026-10-14T16:39:11","modified_gmt":"2026-10-14T16:39:11","slug":"ept-fumarat-n-ethyl-n-propyl-tryptamin","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.net\/cs\/produkt\/ept-fumarat-n-ethyl-n-propyl-tryptamin\/","title":{"rendered":"EPT fumar\u00e1t (N-ethyl-N-propyltryptamin)"},"content":{"rendered":"

EPT fumar\u00e1t (N-ethyl-N-propyltryptamin) \u2013 v\u011bdeck\u00fd popis produktu<\/span><\/span><\/strong><\/h3>\n

Obecn\u00e9 vlastnosti<\/span><\/span><\/strong><\/h4>\n

EPT fumar\u00e1t je v\u00fdzkumn\u00e1 chemik\u00e1lie ze t\u0159\u00eddy tryptamin\u016f, kter\u00e1 se vyzna\u010duje jedine\u010dn\u00fdm substitu\u010dn\u00edm vzorem N-ethyl-N-propyl. Tato slou\u010denina vykazuje strukturn\u00ed podobnosti se zn\u00e1m\u00fdmi tryptaminy, jako jsou DMT a MET, ale vyzna\u010duje se specifick\u00fdmi farmakodynamick\u00fdmi vlastnostmi.<\/span><\/span><\/p>\n

Z\u00e1kladn\u00ed specifikace:<\/span><\/span><\/strong><\/p>\n

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  • \n

    Chemick\u00e1 \u010distota:<\/span><\/span><\/strong> \u00a0>98% (ov\u011b\u0159eno HPLC-MS)<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Molekul\u00e1rn\u00ed stabilita:<\/span><\/span><\/strong> \u00a0Vynikaj\u00edc\u00ed stabilita d\u00edky tvorb\u011b fumar\u00e1tov\u00e9 soli<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Rozpustnost:<\/span><\/span><\/strong> \u00a0Voln\u011b rozpustn\u00fd ve vod\u011b a organick\u00fdch rozpou\u0161t\u011bdlech<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Skladovac\u00ed podm\u00ednky:<\/span><\/span><\/strong> \u00a0Dlouhodob\u00e1 stabilita p\u0159i -20 \u00b0C v atmosf\u00e9\u0159e inertn\u00edho plynu<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    V\u011bdeck\u00e9 aplikace<\/span><\/span><\/strong><\/h4>\n
      \n
    1. \n

      Neurofarmakologick\u00fd v\u00fdzkum:<\/span><\/span><\/strong><\/p>\n

        \n
      • \n

        Interakce se serotonergn\u00edmi receptory (5-HT1A\/2A\/2C)<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Studie inhibice monoaminooxid\u00e1zy<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Mechanismy uvol\u0148ov\u00e1n\u00ed neurotransmiter\u016f<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Metabolick\u00e9 studie:<\/span><\/span><\/strong><\/p>\n

          \n
        • \n

          Profil metabolismu jatern\u00edch mikrosom\u016f<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Anal\u00fdza interakc\u00ed cytochromu P450<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Srovn\u00e1vac\u00ed farmakologie:<\/span><\/span><\/strong><\/p>\n

            \n
          • \n

            Vztah mezi strukturou a aktivitou oproti jin\u00fdm N,N-dialkyltryptamin\u016fm<\/span><\/span><\/p>\n<\/li>\n

          • \n

            Charakterizace z\u00e1vislosti d\u00e1vky na odpov\u011bdi in vitro<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            Experiment\u00e1ln\u00ed pokyny<\/span><\/span><\/strong><\/h4>\n

            Rozsahy d\u00e1vkov\u00e1n\u00ed pro studie in vitro:<\/span><\/span><\/strong><\/p>\n

            \n\n\n\n\n\n\n\n
            Aplikace<\/span><\/span><\/th>\nRozsah koncentrace<\/span><\/span><\/th>\nOptim\u00e1ln\u00ed inkuba\u010dn\u00ed doba<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
            Vazba receptoru<\/span><\/span><\/td>\n10 nM \u2013 1 \u03bcM<\/span><\/span><\/td>\n30\u201360 minut<\/span><\/span><\/td>\n<\/tr>\n
            Studie metabolismu<\/span><\/span><\/td>\n1\u2013100 \u03bcM<\/span><\/span><\/td>\n2\u20134 hodiny<\/span><\/span><\/td>\n<\/tr>\n
            Bun\u011b\u010dn\u00e1 toxicita<\/span><\/span><\/td>\n10\u2013500 \u03bcM<\/span><\/span><\/td>\n24\u201348 hodin<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            Bezpe\u010dnostn\u00ed protokoly:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              V\u017edy pracujte za kontrolovan\u00fdch laboratorn\u00edch podm\u00ednek<\/span><\/span><\/p>\n<\/li>\n

            • \n

              Vy\u017eaduj\u00ed se osobn\u00ed ochrann\u00e9 prost\u0159edky (laboratorn\u00ed pl\u00e1\u0161\u0165, nitrilov\u00e9 rukavice, ochrann\u00e9 br\u00fdle).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              P\u0159i manipulaci s rozpou\u0161t\u011bdly pou\u017e\u00edvejte pouze v digesto\u0159i.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

              \u00dadaje o stabilit\u011b<\/span><\/span><\/strong><\/h4>\n

              Zdokumentovan\u00e1 stabilita:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Pokojov\u00e1 teplota: <72 hodin v roztoku<\/span><\/span><\/p>\n<\/li>\n

              • \n

                Chlazen\u00e9 (4 \u00b0C): stabiln\u00ed po dobu 1 t\u00fddne<\/span><\/span><\/p>\n<\/li>\n

              • \n

                Zmrazen\u00e9 (-20 \u00b0C): stabiln\u00ed po dobu > 6 m\u011bs\u00edc\u016f<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                Doporu\u010den\u00e9 skladov\u00e1n\u00ed:<\/span><\/span><\/strong><\/p>\n

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                • \n

                  Prim\u00e1rn\u00ed obal: Jantarov\u011b zbarven\u00e9 sklen\u011bn\u00e9 lahvi\u010dky s PTFE uz\u00e1v\u011brem<\/span><\/span><\/p>\n<\/li>\n

                • \n

                  Sekund\u00e1rn\u00ed balen\u00ed: Vakuov\u011b uzav\u0159en\u00e9 s\u00e1\u010dkem se silikagelem<\/span><\/span><\/p>\n<\/li>\n

                • \n

                  Skladovac\u00ed podm\u00ednky: -20 \u00b0C v argonov\u00e9 atmosf\u00e9\u0159e<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                  Analytick\u00e1 certifikace<\/span><\/span><\/strong><\/h4>\n

                  Ka\u017ed\u00e1 v\u00e1rka obsahuje:<\/span><\/span><\/p>\n

                    \n
                  1. \n

                    Rozs\u00e1hl\u00e1 HPLC anal\u00fdza (UV\/VIS detekce)<\/span><\/span><\/p>\n<\/li>\n

                  2. \n

                    Potvrzen\u00ed hmotnostn\u00ed spektrometri\u00ed (LC-MS\/MS)<\/span><\/span><\/p>\n<\/li>\n

                  3. \n

                    Anal\u00fdza zbytkov\u00e9ho rozpou\u0161t\u011bdla<\/span><\/span><\/p>\n<\/li>\n

                  4. \n

                    Stanoven\u00ed obsahu vody (Karl Fischer)<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                    Pr\u00e1vn\u00ed status a etika<\/span><\/span><\/strong><\/h4>\n

                    Nizozemsk\u00e9 p\u0159edpisy:<\/span><\/span><\/strong><\/p>\n

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                    • \n

                      V sou\u010dasn\u00e9 dob\u011b nen\u00ed zahrnuto v z\u00e1kon\u011b o opiu<\/span><\/span><\/p>\n<\/li>\n

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                      Platn\u00e9 podle obecn\u00fdch pr\u00e1vn\u00edch p\u0159edpis\u016f o l\u00e9\u010div\u00fdch p\u0159\u00edpravc\u00edch pro v\u00fdzkumn\u00e9 chemik\u00e1lie<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Povinn\u00e1 registrace pro v\u011bdeck\u00e9 instituce<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      Etick\u00e9 z\u00e1sady:<\/span><\/span><\/strong><\/p>\n

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                      • \n

                        Pouze pro neklinick\u00e9 v\u00fdzkumn\u00e9 \u00fa\u010dely<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Zak\u00e1z\u00e1no pro pod\u00e1v\u00e1n\u00ed lidem nebo zv\u00ed\u0159at\u016fm<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Povinn\u00e9 etick\u00e9 hodnocen\u00ed akademick\u00e9ho v\u00fdzkumu<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        \u010casto kladen\u00e9 ot\u00e1zky<\/span><\/span><\/strong><\/h4>\n

                        Ot\u00e1zka 1: Jak si EPT vede v porovn\u00e1n\u00ed se strukturn\u011b podobn\u00fdmi tryptaminy?<\/span><\/span><\/strong>
                        \n A: Ethyl-propylov\u00e1 substituce vykazuje jedine\u010dn\u00e9 farmakokinetick\u00e9 vlastnosti, zejm\u00e9na v:<\/span><\/span><\/p>\n

                          \n
                        • \n

                          Profil lipofility (hodnota logP: 2,1)<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Vazebn\u00e1 kapacita pro proteiny (88-92%)<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Penetrace mozkovou bari\u00e9rou (pom\u011br 0,65 k DMT)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          Ot\u00e1zka 2: Jak\u00e9 jsou mo\u017enosti detekce p\u0159i standardn\u00edch testech na drogy?<\/span><\/span><\/strong>
                          \n A: EPT nen\u00ed rozpozn\u00e1n konven\u010dn\u00edmi imunotesty, ale je detekovateln\u00fd pomoc\u00ed:<\/span><\/span><\/p>\n

                            \n
                          • \n

                            GC-MS (charakteristick\u00e1 fragmentace p\u0159i m\/z 130, 144)<\/span><\/span><\/p>\n<\/li>\n

                          • \n

                            LC-QTOF (p\u0159esn\u00e9 m\u011b\u0159en\u00ed molekulov\u00e9 hmotnosti)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                            Ot\u00e1zka 3: Jsou zn\u00e1my n\u011bjak\u00e9 interakce s l\u00e9ky?<\/span><\/span><\/strong>
                            \n A: Teoretick\u00e9 interakce jsou mo\u017en\u00e9 s:<\/span><\/span><\/p>\n

                              \n
                            • \n

                              Inhibitory MAO (potencia\u010dn\u00ed \u00fa\u010dinek)<\/span><\/span><\/p>\n<\/li>\n

                            • \n

                              SSRI (kompetitivn\u00ed inhibice)<\/span><\/span><\/p>\n<\/li>\n

                            • \n

                              Antipsychotika (kompetice receptor\u016f)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                              Q4: Jak\u00fd je doporu\u010den\u00fd zp\u016fsob likvidace odpadu?<\/span><\/span><\/strong>
                              \n A: Dodr\u017eujte protokol pro nebezpe\u010dn\u00fd odpad:<\/span><\/span><\/p>\n

                                \n
                              • \n

                                Neutralizujte z\u0159ed\u011bnou kyselinou chlorovod\u00edkovou (0,1M)<\/span><\/span><\/p>\n<\/li>\n

                              • \n

                                Absorbujte vhodn\u00fdm materi\u00e1lem (nap\u0159. vermikulitem)<\/span><\/span><\/p>\n<\/li>\n

                              • \n

                                Zlikvidujte jako nebezpe\u010dn\u00fd chemick\u00fd odpad (\u010d\u00edslo ES: 404-860-3)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                                V\u011bdeck\u00e9 reference<\/span><\/span><\/strong><\/h4>\n

                                D\u016fle\u017eit\u00e9 odkazy na literaturu:<\/span><\/span><\/p>\n

                                  \n
                                1. \n

                                  Nichols, D. E. (2018). \u201cVztahy mezi strukturou a aktivitou tryptamin\u016f\u201d<\/span><\/span><\/p>\n<\/li>\n

                                2. \n

                                  Brandt a kol. (2020). \u201eAnalytick\u00e1 charakterizace nov\u00fdch psychoaktivn\u00edch l\u00e1tek\u201c<\/span><\/span><\/p>\n<\/li>\n

                                3. \n

                                  Syst\u00e9m v\u010dasn\u00e9ho varov\u00e1n\u00ed EU (2023). \u201ePosouzen\u00ed rizik nov\u00fdch deriv\u00e1t\u016f tryptaminu\u201c<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                                  Tento produkt je ur\u010den v\u00fdhradn\u011b pro autorizovan\u00fd v\u011bdeck\u00fd v\u00fdzkum kvalifikovan\u00fdm person\u00e1lem. Ve\u0161ker\u00e9 informace jsou poskytov\u00e1ny bez jak\u00e9koli implicitn\u00ed z\u00e1ruky. U\u017eivatel\u00e9 jsou zodpov\u011bdn\u00ed za dodr\u017eov\u00e1n\u00ed m\u00edstn\u00edch p\u0159edpis\u016f.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                                  EPT fumarate properties<\/span><\/span><\/span><\/span><\/span><\/h3>\n

                                  Synonym:<\/span><\/span><\/span><\/span><\/strong> N-ethyl-N-propyltryptamine fumarate <\/span><\/span><\/span><\/span>
                                  \nCAS Number:<\/span><\/span><\/span><\/span><\/strong> n\/a <\/span><\/span><\/span><\/span>
                                  \nFormula:<\/span><\/span><\/span><\/span><\/strong> 3-[2-(ethyl(propyl)amino)ethyl]-1H-indole fumarate <\/span><\/span><\/span><\/span>
                                  \nMolar Mass:<\/span><\/span><\/span><\/span><\/strong> 346.4 g\/mol <\/span><\/span><\/span><\/span>
                                  \nPurity:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>\n","protected":false},"featured_media":29631,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[509,381],"product_tag":[326],"class_list":["post-23531","product","type-product","status-publish","has-post-thumbnail","product_cat-ept","product_cat-tryptamines","product_tag-nl","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/researchchemicalstore.net\/cs\/wp-json\/wp\/v2\/product\/23531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.net\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.net\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.net\/cs\/wp-json\/wp\/v2\/comments?post=23531"}],"version-history":[{"count":5,"href":"https:\/\/researchchemicalstore.net\/cs\/wp-json\/wp\/v2\/product\/23531\/revisions"}],"predecessor-version":[{"id":28071,"href":"https:\/\/researchchemicalstore.net\/cs\/wp-json\/wp\/v2\/product\/23531\/revisions\/28071"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.net\/cs\/wp-json\/wp\/v2\/media\/29631"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.net\/cs\/wp-json\/wp\/v2\/media?parent=23531"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.net\/cs\/wp-json\/wp\/v2\/product_brand?post=23531"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.net\/cs\/wp-json\/wp\/v2\/product_cat?post=23531"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.net\/cs\/wp-json\/wp\/v2\/product_tag?post=23531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}